Krüppel-like factor 3 (KLF3) suppresses NF-κB–driven inflammation in mice
Alexander J. Knights, Lu Yang, Manan Shah, Laura J. Norton, Gamran S. Green, Elizabeth S. Stout, Emily J. Vohralik, Merlin Crossley, Kate Quinlan
Abstract
monocytes and macrophage-derived inflammatory cytokines. These findings reveal that KLF3 is a fundamental suppressor that operates as a feedback inhibitor of RELA/p65 and may be important in facilitating the resolution of inflammation.
Topics & Concepts
InflammationTranscription factorImmunologyCytokineNF-κBBiologySuppressorCancer researchCell biologyGeneGeneticsKruppel-like factors researchPeroxisome Proliferator-Activated ReceptorsGenomics, phytochemicals, and oxidative stress