I<sub>2</sub>-Catalyzed transformation of <i>o</i>-aminobenzamide to <i>o</i>-ureidobenzonitrile using isothiocyanates
Sadashivamurthy Shamanth, Nagaraju Chaithra, Mahesha Gurukiran, M. Mamatha, N.K. Lokanath, Kanchugarakoppal S. Rangappa, Kempegowda Mantelingu
Abstract
The present work describes an unexpected and unique protocol for the iodine catalysed synthesis of o-ureidobenzonitriles using o-aminobenzamides and isothiocyanates via intramolecular rearrangement. The metal-free route achieved here is insensitive to moisture and applicable to the synthesis of a wide variety of o-ureidobenzonitriles with excellent yields even in a scalable fashion.
Topics & Concepts
ChemistryCatalysisTransformation (genetics)Combinatorial chemistryMedicinal chemistryOrganic chemistryBiochemistryGeneQuinazolinone synthesis and applicationsSynthesis and Catalytic ReactionsSynthesis and Biological Evaluation