The role of long non‐coding <scp>RNAs</scp> and downstream signaling pathways in leukemia progression
Yadong Liu, Penghao Sun, Yuhao Zhao, Bin Liu
Abstract
The study of long non-coding RNAs (lncRNA) is a newly established field and our knowledge about them is rapidly growing. These kinds of RNAs are unchanged parts of the genome throughout evolution, that modulate cell growth, differentiation, and apoptosis during diverse physiological and pathological processes including leukemia development. They have the capability to be useful biomarkers for the diagnosis, clinical typing, prognosis, as well as potential therapeutic targets. In this study, we summarized the role of lncRNAs in the expression and function of white blood cells and oncogenic transformation into four main types of leukemia.
Topics & Concepts
BiologyLeukemiaSignal transductionLong non-coding RNAFunction (biology)ApoptosisComputational biologyGenomeCancer researchRNACell biologyGeneticsGeneCancer-related molecular mechanisms researchCircular RNAs in diseasesMycobacterium research and diagnosis