Levels of the TNF-Related Cytokine LIGHT Increase in Hospitalized COVID-19 Patients with Cytokine Release Syndrome and ARDS
David S. Perlin, Inbal Zafir‐Lavie, Lori Roadcap, Shane Raines, Carl F. Ware, Garry A. Neil
Abstract
= 0.0076) higher levels observed in patients who died than in survivors, paralleling the LIGHT levels. Although attempts to block IL-6 binding to its receptor have shown limited success in COVID-19 CRS, neutralization of LIGHT may prove to be more effective owing to its more central role in regulating antiviral immune responses. The findings presented here demonstrate that LIGHT is a cytokine which may play an important role in COVID-19 patients presenting with acute respiratory distress syndrome (ARDS) and CRS and suggest that LIGHT neutralization may be beneficial to COVID-19 patients.
Topics & Concepts
ARDSCytokineCytokine release syndromeCoronavirus disease 2019 (COVID-19)MedicineTumor necrosis factor alphaSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakImmunologyCytokine stormInternal medicineVirologyLungOutbreakDiseaseInfectious disease (medical specialty)Long-Term Effects of COVID-19COVID-19 Clinical Research StudiesIntensive Care Unit Cognitive Disorders