Folic acid-mediated fibrosis is driven by C5a receptor 1-mediated activation of kidney myeloid cells
Ranjit Kumar Sahu, Sandhya Xavier, Daniel Chauss, Luopin Wang, Claude Chew, Ronald P. Taylor, William B. Stallcup, Z. Jennie, Majid Kazemian, Behdad Afzali, Jörg Köhl, Didier Portilla
Abstract
This study used novel green fluorescent protein C5a receptor 1 floxed mice and the model of folic acid-mediated kidney fibrosis to demonstrate the pathogenic role of increased expression of this complement receptor on macrophages.
Topics & Concepts
FibrosisFolic acidReceptorMyeloid cellsKidneyMyeloidMedicineChemistryCancer researchInternal medicineAcute Kidney Injury ResearchDrug Transport and Resistance MechanismsPhagocytosis and Immune Regulation