Reproducibility, reliability and variability of FA and MD in the older healthy population: A test-retest multiparametric analysis
Pedro Luque Laguna, Anna Combes, Johannes Streffer, Steven Einstein, Maarten Timmers, Steven Williams, Flavio Dell’Acqua
Abstract
• In older healthy subjects, FA and MD show overall good test-retest reliability & reproducibility. • MD is sistematically more reproducible than FA across the entire brain anatomy. • FA is more reliable than MD in subcortical white matter regions. • In high reliability & low reproducibility regions, variability between subjects is high and statistical power is low. • In low reliability & high reproducibility regions, variability between subjects is low and statistical power is high.
Topics & Concepts
ReproducibilityReliability (semiconductor)PopulationMedicinePsychologyNuclear medicineStatisticsPower (physics)MathematicsEnvironmental healthPhysicsQuantum mechanicsAdvanced Neuroimaging Techniques and ApplicationsStatistical Methods and InferenceStatistical Methods and Bayesian Inference