Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing
Mariko Kanai, Tomas Yeo, Victor Asua, Philip J. Rosenthal, David A. Fidock, Sachel Mok
Abstract
SNP-editing, identify novel recombinant genetic cross progeny, or cluster strains to infer their geographical origins. Results were compared with Illumina-based whole-genome sequence analysis that provides the most detailed sequence information but is cost-prohibitive. These adaptable, simple, and inexpensive methods can be easily implemented into routine genotyping of P. falciparum parasites in both laboratory and field settings.
Topics & Concepts
GenotypingBiologyPlasmodium falciparumMicrosatelliteGeneticsTypingSNPComputational biologyGenotypeSNP genotypingSingle-nucleotide polymorphismMultilocus sequence typingDrug resistanceSequence analysisGenetic markerGenetic analysisDNA sequencingLineage (genetic)HaplotypeSNP arrayMalariaVirologyMolecular epidemiologyMalaria Research and Controlvaccines and immunoinformatics approachesPharmaceutical Quality and Counterfeiting