Iridium-catalyzed C–H amidation of <i>s</i>-tetrazines
Huan Xiong, Yuang Gu, Shuning Zhang, Fengping Lu, Qun Ji, Lili Liu, Peixiang Ma, Guang Yang, Wei Hou, Hongtao Xu
Abstract
An efficient, selective and scalable C-H amidation of s-tetrazines under iridium(III) catalysis is reported. This reaction features a broad substrate scope, high functional group tolerance, and air and water tolerance. This reaction also shows great potential for the rapid preparation of tri- and tetra-functional building blocks, which can be applied either in bioconjugation or synthesis of DNA-encoded library.
Topics & Concepts
BioconjugationIridiumCatalysisSubstrate (aquarium)Combinatorial chemistryChemistryFunctional groupTetraScope (computer science)Organic chemistryMedicinal chemistryComputer scienceBiologyProgramming languageEcologyPolymerClick Chemistry and ApplicationsSynthesis and Biological EvaluationChemical Synthesis and Analysis