The ubiquitin ligase UBE4B regulates amyloid precursor protein ubiquitination, endosomal trafficking, and amyloid β42 generation and secretion
Monica Gireud, Sahily Reyes‐Esteves, Ritika Tewari, Anthony Patrizz, Matthew D. Howe, Julia Kofler, M. Neal Waxham, Louise D. McCullough, Andrew J. Bean
Topics & Concepts
EndosomeESCRTUbiquitinUbiquitin ligaseCell biologyBiologyEndocytic cycleAmyloid precursor proteinAlpha secretaseEndocytosisBiochemistryAlzheimer's diseaseIntracellularInternal medicineReceptorGeneDiseaseMedicineAlzheimer's disease research and treatmentsCellular transport and secretionUbiquitin and proteasome pathways