Bioorthogonal regulation of DNA circuits for smart intracellular microRNA imaging
Yingying Chen, Xue Gong, Yuhui Gao, Yu Shang, Jinhua Shang, Shanshan Yu, Ruomeng Li, Shizhen He, Xiaoqing Liu, Fuan Wang
Abstract
the multiply guaranteed molecular recognition/activation procedures. This bioorthogonal regulated DNA circuit presents a modular and programmable amplification strategy for highly reliable assays of intracellular biomarkers, and provides a pivotal molecular toolbox for living systems.
Topics & Concepts
IntracellularBioorthogonal chemistryDNAmicroRNAChemistryComputational biologyCell biologyBiologyBiochemistryCombinatorial chemistryGeneClick chemistryAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryBiosensors and Analytical Detection