Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition
Carien Dekker, Henri Mattes, Michael Wright, Andreas Boettcher, Alexandra Hinniger, Nicola Hughes, Sandra Kapps-Fouthier, Jörg Eder, P. Erbel, Nikolaus Stiefl, Angela Mackay, Christopher J. Farady
Topics & Concepts
InflammasomePyrin domainChemistryInnate immune systemIntramolecular forceFunction (biology)Cell biologyProtein structureMechanism (biology)StereochemistryBiochemistryBiologyReceptorPhysicsQuantum mechanicsInflammasome and immune disordersHeme Oxygenase-1 and Carbon Monoxideinterferon and immune responses