Comparative Analytical Evaluation of Four Centralized Platforms for the Detection of Mycobacterium tuberculosis Complex and Resistance to Rifampicin and Isoniazid
Margaretha de Vos, Lesley Scott, Anura David, André Trollip, Harald Hoffmann, Sophia B. Georghiou, Sergio Carmona, Morten Rühwald, Wendy Stevens, Claudia M. Denkinger, Samuel G. Schumacher
Abstract
Failure to rapidly identify drug-resistant tuberculosis (TB) increases the risk of patient mismanagement, the amplification of drug resistance, and ongoing transmission. We generated comparative analytical data for four automated assays for the detection of TB and multidrug-resistant TB (MDR-TB): Abbott RealTi m e MTB and MTB RIF/INH (Abbott), Hain Lifescience FluoroType MTBDR (Hain), BD Max MDR-TB (BD), and Roche cobas MTB and MTB-RIF/INH (Roche).
Topics & Concepts
Mycobacterium tuberculosisRifampicinIsoniazidTuberculosisVirologyMedicineMicrobiologyMycobacterium tuberculosis complexDrug resistanceBiologyPathologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisPneumonia and Respiratory Infections