Design and synthesis of novel substituted indole-acrylamide derivatives and evaluation of their anti-cancer activity as potential tubulin-targeting agents
Mohammed Hawash, Deniz Kahraman, Abdurrahman Olğaç, Sezen Güntekin Ergün, Ernest Hamel, Rengül Çetin-Atalay, Sultan Nacak Baytaş
Topics & Concepts
ChemistryTubulinIndole testAcrylamideMicrotubulePolymerizationLinkerMicrotubule polymerizationColchicineIn vitroCancer cellStereochemistryBiochemistryCombinatorial chemistryMonomerCancerOrganic chemistryCell biologyPolymerBiologyOperating systemInternal medicineMedicineComputer scienceSynthesis and biological activitySynthesis and Biological EvaluationSynthesis of β-Lactam Compounds