Optical control of the β2-adrenergic receptor with opto-prop-2: A cis-active azobenzene analog of propranolol
Reggie Bosma, Nicola C. Dijon, Yang Zheng, Hannes Schihada, Niels J. Hauwert, Shuang Shi, Marta Arimont, Rick Riemens, Hans Custers, Andrea van de Stolpe, Henry F. Vischer, Maikel Wijtmans, Nicholas D. Holliday, Diederik W.D. Kuster, Rob Leurs
Abstract
-AR sensor, by the recruitment of downstream effector proteins and functional modulation of isolated adult rat cardiomyocytes.
Topics & Concepts
AzobenzenePropranololChemistryIsomerizationReceptorAdrenergic receptorAffinitiesBiophysicsAntagonistStereochemistryAllosteric regulationMoleculeBiochemistryBiologyOrganic chemistryEndocrinologyCatalysisPhotochromic and Fluorescence ChemistryPhotoreceptor and optogenetics researchReceptor Mechanisms and Signaling