Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction
Rebecca Crawshaw, Amy E. Crossley, Linus O. Johannissen, Ashleigh J. Burke, Sam Hay, Colin Levy, David Baker, Sarah L. Lovelock, Anthony P. Green
Topics & Concepts
Enantioselective synthesisChemistryNucleophileDirected evolutionCatalysisCombinatorial chemistryBiocatalysisProtein designAldehydeBaylis–Hillman reactionStereochemistryOrganic chemistryReaction mechanismProtein structureBiochemistryMutantGeneEnzyme Catalysis and ImmobilizationSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis