Maleimide-Decorated PEGylated Mucoadhesive Liposomes for Ocular Drug Delivery
Roman V. Moiseev, Daulet B. Kaldybekov, Sergey K. Filippov, Aurel Rădulescu, Vitaliy V. Khutoryanskiy
Abstract
corneal and conjunctival retention of these liposomes were examined using the fluorescence flow-through method. Maleimide-decorated liposomes exhibited the best retention performance on bovine conjunctiva compared to other types of liposomes studied. Poor retention of all liposomal formulations was observed on bovine cornea.
Topics & Concepts
LiposomeDynamic light scatteringVesicleDrug deliveryChemistryMaleimideZeta potentialMucoadhesionBiophysicsChromatographyDrug carrierMaterials scienceNanoparticleNanotechnologyMembraneBiochemistryOrganic chemistryBiologyAdvanced Drug Delivery SystemsRNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery