<i>hapE</i> and <i>hmg1</i> Mutations Are Drivers of <i>cyp51A</i> -Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical Isolate
Ana Camila Oliveira Souza, Wenbo Ge, Nathan P. Wiederhold, Jeffrey M. Rybak, Jarrod R. Fortwendel, P. David Rogers
Abstract
Triazole resistance is an important cause of treatment failure and high mortality rates for A. fumigatus human infections. Although Cyp51A-associated mutations are frequently identified as the cause of A. fumigatus triazole resistance, they do not explain the resistance phenotypes for several isolates.
Topics & Concepts
Aspergillus fumigatusPhenotypeTriazoleBiologyMicrobiologyResistance (ecology)GeneticsGeneChemistryEcologyOrganic chemistryAntifungal resistance and susceptibilityPeptidase Inhibition and AnalysisFungal Infections and Studies