Legacy of the discovery of the T-cell receptor: 40 years of shaping basic immunology and translational work to develop novel therapies
Yufang Shi, Andreas Strasser, Douglas R. Green, Eicke Latz, Alberto Mantovani, Gerry Melino
Abstract
Forty years have passed since the groundbreaking achievement of cloning T-cell receptor genes [ 1 , 2 ]. The rich narrative that sets the stage for this significant event is incredibly striking, and its profound legacy in contemporary immunology and medical science is truly remarkable.
Topics & Concepts
Translational researchWork (physics)ReceptorMedicineNeuroscienceImmunologyComputational biologyBiologyEngineeringInternal medicinePathologyMechanical engineeringCAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell Immunology