Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors
Yongfang Yao, Tao Huang, Yuyang Wang, Longfei Wang, Siqi Feng, Weyland Cheng, Longhua Yang, Yongtao Duan
Abstract
could be considered an effective anti-angiogenesis and -leukaemia drug candidate that binds to the tubulin colchicine site.
Topics & Concepts
AngiogenesisColchicineTubulinChemistryZebrafishIC50MicrotubuleIn vivoPharmacologyIn vitroBiochemistryMolecular biologyBiologyCell biologyCancer researchBiotechnologyGeneticsGeneSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsQuinazolinone synthesis and applications