Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation
Dhulfiqar Ali Abed, Sumi Lee, Wen Xia, Ahmed R. Ali, Vaibhav S. Mangipudy, Lauren M. Aleksunes, Longqin Hu
Topics & Concepts
ChemistryNeuroinflammationKEAP1Oxidative stressCytotoxicityReactive oxygen speciesMicrogliaIn vivoLipopolysaccharideWestern blotTumor necrosis factor alphaBiochemistryInflammationIn vitroPharmacologyTranscription factorGeneImmunologyMedicineBiologyBiotechnologyGenomics, phytochemicals, and oxidative stressTryptophan and brain disordersRedox biology and oxidative stress