A comprehensive analysis of Rab GTPases reveals a role for Rab34 in serum starvation-induced primary ciliogenesis
Mai E. Oguchi, Koki Okuyama, Yuta Homma, Mitsunori Fukuda
Abstract
Rab interacting lysosomal protein [RILP]), a unique long N-terminal region of Rab34 before the conserved GTPase domain was found to be essential. These findings suggest that Rab34 is an atypical Rab that regulates serum starvation-induced ciliogenesis through its unique N-terminal region.
Topics & Concepts
CiliogenesisRabBiologyCell biologyGTPaseCiliumEffectorSmall GTPaseSignal transductionGenetic and Kidney Cyst DiseasesRenal and related cancersHedgehog Signaling Pathway Studies