Regioselective C(sp<sup>3</sup>)–H amidation of 8-methylquinolines with <i>N</i>-hydroxyphthalimides
Rohit Kumar, Diksha Parmar, Devesh Chandra, Sarthi, Upendra Sharma
Abstract
)-H amidation of 8-ethylquinolines. Besides that, the reaction is also applicable for the gram-scale synthesis of the amidated product. In addition, the late-stage amidation of santonin oxime as well as carvone oxime and the diversification of the amidated product was also carried out to illustrate the relevance of the developed methodology. Mechanistic studies revealed that the current reaction proceeds through a five-membered rhodacycle intermediate and does not involve the radical pathway.
Topics & Concepts
RegioselectivityChemistryOximeCombinatorial chemistryStereochemistryOrganic chemistryMedicinal chemistryCatalysisCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCatalytic Cross-Coupling Reactions