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CLUSTER guide RNAs enable precise and efficient RNA editing with endogenous ADAR enzymes in vivo

Philipp Reautschnig, Nicolai Wahn, Jacqueline Wettengel, Annika E. Schulz, Ngadhnjim Latifi, Paul Vogel, Tae-Won Kang, Laura S. Pfeiffer, Christine Zarges, Ulrike Naumann, Lars Zender, Jin Billy Li, Thorsten Stafforst

2022Nature Biotechnology111 citationsDOI

Topics & Concepts

Guide RNARNA editingADARRNAComputational biologyBiologyGenome editingCas9Competing endogenous RNAMessenger RNACRISPRCluster (spacecraft)Cre recombinaseGeneticsmicroRNAAdenosine deaminaseIntronSynthetic biologyRecombinaseRibozymeRNA regulation and diseaseCRISPR and Genetic EngineeringNuclear Structure and Function
CLUSTER guide RNAs enable precise and efficient RNA editing with endogenous ADAR enzymes in vivo | Litcius