A brief comparison of polygenic risk scores and Mendelian randomisation
Victoria Garfield, Emma L. Anderson
Abstract
Mendelian randomisation and polygenic risk score analysis have become increasingly popular in the last decade due to the advent of large-scale genome-wide association studies. Each approach has valuable applications, some of which are overlapping, yet there are important differences which we describe here.
Topics & Concepts
Polygenic risk scoreMendelian inheritanceHuman geneticsGenome-wide association studyBiologyMultifactorial InheritanceMendelian randomizationGeneticsBioinformaticsComputational biologySingle-nucleotide polymorphismGenetic variantsGenotypeGeneGenetic Associations and EpidemiologyGenetic and phenotypic traits in livestockGenetic Mapping and Diversity in Plants and Animals