Litcius/Paper detail

Aspirin protects against genotoxicity by promoting genome repair

Hui Jiang, Patrycja Swacha, Kyaw Min Aung, Nelson O. Gekara

2023Cell Research15 citationsDOIOpen Access PDF

Abstract

Radiation sickness is a major health concern. 1 The quest for radiation countermeasures started in the wake of the devastation witnessed following the nuclear detonations during the Second World War and has continued through the subsequent radiological accidents around the world. A radioprotector is also required for prophylactic use by staff working at radiation sources, pilots, and astronauts at high risk of space radiation, or patients undertaking lengthy radiological procedures. Despite decades of research, a safe, efficient, and cost-effective radioprotector is yet to be unveiled.

Topics & Concepts

BiologyGenotoxicityAspirinGenomeGeneticsComputational biologyBioinformaticsGeneToxicityInternal medicineBiochemistryMedicineCancer therapeutics and mechanismsinterferon and immune responsesHIV/AIDS drug development and treatment