Design, synthesis, and evaluation of novel matrine derivatives as topoisomerase I inhibitors for anticancer agents
Guanghuan Shen, Yu Zhu, Shihao Li, Xi Yu, Zheng Xu, Xuan Liu, Chunyan Lv, Linlin Cui, Zhihua Xing
Topics & Concepts
ChemistryMatrineTopoisomeraseStereochemistryPharmacologyCombinatorial chemistryBiochemistryEnzymeMedicineChromatographyCancer therapeutics and mechanismsSynthesis and biological activityBioactive Compounds and Antitumor Agents