Apocynin abrogates methotrexate-induced nephrotoxicity: role of TLR4/NF-κB-p65/p38-MAPK, IL-6/STAT-3, PPAR-γ, and SIRT1/FOXO3 signaling pathways
Emad H. M. Hassanein, Ahmed M. Sayed, Omnia A. M. Abd El‐Ghafar, Zainab Omar, Eman K. Rashwan, Zuhair M. Mohammedsaleh, So Young Kyung, Jae Hyeon Park, Hyung Sik Kim, Fares E.M. Ali
Topics & Concepts
PharmacologyNephrotoxicityApocyninChemistryMAPK/ERK pathwayp38 mitogen-activated protein kinasesOxidative stressSignal transductionToxicityMedicineNADPH oxidaseBiochemistryOrganic chemistryReproductive System and PregnancyChemotherapy-induced organ toxicity mitigationAcute Lymphoblastic Leukemia research