Elucidating the Kinetic Mechanism of Human METTL16
Kurtis Breger, Jessica A. Brown
Abstract
, suggesting that the missing vertebrate conserved regions weaken the ternary complex but do not induce any rate-limiting conformational rearrangements of the U6 snRNA. This study helps us to better understand the catalytic activity of METTL16 in the context of its biological functions.
Topics & Concepts
Small nuclear RNAMethylationTernary complexChemistryMethyltransferaseRNADissociation constantPrp24StereochemistryBiochemistryBiologyBiophysicsEnzymeRNA splicingNon-coding RNADNAGeneReceptorRNA modifications and cancerCancer-related gene regulationCancer-related molecular mechanisms research