Biomimetic Total Synthesis of the Rubiginosin Meroterpenoids
Laura Burchill, Aaron J. Day, Oussama Yahiaoui, Jonathan H. George
Abstract
meroterpenoids rubiginosins A and G, which both contain unusual 6-6-6-4 ring systems, has been achieved using a bioinspired cascade approach. Stepwise synthesis of these natural products, and the related 6-6-5-4 meroterpenoids fastinoid B and rhodonoid B, from naturally occurring chromene precursors is also reported.
Topics & Concepts
ChemistryTotal synthesisRing (chemistry)CascadeStereochemistryTerpeneBiomimetic synthesisCombinatorial chemistryOrganic chemistryChromatographyTraditional and Medicinal Uses of AnnonaceaeMarine Sponges and Natural ProductsPlant biochemistry and biosynthesis