Important Roles of <scp>PI3K</scp> / <scp>AKT</scp> Signaling Pathway and Relevant Inhibitors in Prostate Cancer Progression
Rui Wang, Zhen Qu, Ying Lv, Lu Yao, Qian Yang, Xiangyu Zhang, Longquan Xiang
Abstract
Prostate cancer (PCa) is an extremely common malignant tumor of the male genitourinary system, originating from the prostate gland epithelium. Male patients are prone to relapse after treatment, which seriously threatens their health. Phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB, also known as Akt) plays an important role in the growth, invasion, and metastasis of PCa. This review aimed to present an overview of the mechanism of action of the PI3K/AKT signaling pathway in PCa and discuss the application prospects of inhibitors of this pathway in treating PCa, providing a theoretical basis and reference for its clinical treatment targets.
Topics & Concepts
PI3K/AKT/mTOR pathwayProstate cancerProtein kinase BSignal transductionCancerCancer researchProstateBiologyMedicineCell biologyInternal medicineProstate Cancer Treatment and ResearchPI3K/AKT/mTOR signaling in cancerHistone Deacetylase Inhibitors Research