tRNA <sup>fMet</sup> Inactivating Mycobacterium tuberculosis VapBC Toxin-Antitoxin Systems as Therapeutic Targets
Unnati Chauhan, Valdir C. Barth, Nancy A. Woychik
Abstract
The Mycobacterium tuberculosis genome contains an abundance of toxin-antitoxin (TA) systems, 50 of which belong to the VapBC family. The activity of VapC toxins is controlled by dynamic association with their cognate antitoxins—the toxin is inactive when complexed with VapB antitoxin but active when freed.
Topics & Concepts
AntitoxinMycobacterium tuberculosisBiologyRNATransfer RNAToxinMicrobiologyBiochemistryTuberculosisGenePathologyMedicineMycobacterium research and diagnosisTuberculosis Research and EpidemiologyBacterial Genetics and Biotechnology