A Randomized, Controlled Trial of Resistance Training Added to Caloric Restriction Plus Aerobic Exercise Training in Obese Heart Failure With Preserved Ejection Fraction
Peter H. Brubaker, Barbara J. Nicklas, Denise K. Houston, W. Gregory Hundley, Haiying Chen, Anthony Molina, W. Mary Lyles, Benjamin Nelson, Bharathi Upadhya, Russell Newland, Dalane W. Kitzman
Abstract
Background: We have shown that combined caloric restriction (CR) and aerobic exercise training (AT) improve peak exercise O 2 consumption (VO 2peak ), and quality-of-life in older patients with obese heart failure with preserved ejection fraction. However, ≈35% of weight lost during CR+AT was skeletal muscle mass. We examined whether addition of resistance training (RT) to CR+AT would reduce skeletal muscle loss and further improve outcomes. Methods: This study is a randomized, controlled, single-blind, 20-week trial of RT+CR+AT versus CR+AT in 88 patients with chronic heart failure with preserved ejection fraction and body mass index (BMI) ≥28 kg/m 2 . Outcomes at 20 weeks included the primary outcome (VO 2peak ); MRI and dual X-ray absorptiometry; leg muscle strength and quality (leg strength ÷ leg skeletal muscle area); and Kansas City Cardiomyopathy Questionnaire. Results: Seventy-seven participants completed the trial. RT+CR+AT and CR+AT produced nonsignificant differences in weight loss: mean (95% CI): –8 (–9, –7) versus –9 (–11, –8; P =0.21). RT+CR+AT and CR+AT had non-significantly differences in the reduction of body fat [–6.5 (–7.2, –5.8) versus –7.4 (–8.1, –6.7) kg] and skeletal muscle [–2.1 (–2.7, –1.5) versus –2.1 (–2.7, –1.4) kg] ( P =0.20 and 0.23, respectively). RT+CR+AT produced significantly greater increases in leg muscle strength [4.9 (0.7, 9.0) versus –1.1 (–5.5, 3.2) Nm, P =0.05] and leg muscle quality [0.07 (0.03, 0.11) versus 0.02 (–0.02, 0.06) Nm/cm 2 , P =0.04]. Both RT+CR+AT and CR+AT produced significant improvements in VO 2peak [108 (958, 157) versus 80 (30, 130) mL/min; P =0.001 and 0.002, respectively], and Kansas City Cardiomyopathy Questionnaire score [17 (12, 22) versus 23 (17, 28); P =0.001 for both], with no significant between-group differences. Both RT+CR+AT and CR+AT significantly reduced LV mass and arterial stiffness. There were no study-related serious adverse events. Conclusions: In older obese heart failure with preserved ejection fraction patients, CR+AT produces large improvements in VO 2peak and quality-of-life. Adding RT to CR+AT increased leg strength and muscle quality without attenuating skeletal muscle loss or further increasing VO 2peak or quality-of-life. Registration: URL: https://ClincalTrials.gov ; Unique identifier: NCT02636439.