CAR T cell research has quickly advanced from the bench to the clinic and back. The results of the trials have revealed new mechanisms
Moataz Dowaidar
Abstract
CAR T cell research has fast progressed into the clinic and now back to the bench, with trial outcomes exposing new mechanisms of efficacy, toxicity, and resistance, and sparking the hunt for additional targets, clarification of signaling systems, and application of newer technology. CAR design, transduction methods, and cell type selection are all predicted to improve responses and change therapy for patients with a variety of malignancies.
Topics & Concepts
Bench to bedsideVariety (cybernetics)Transduction (biophysics)Clinical trialSelection (genetic algorithm)MedicineComputer scienceMedical physicsBiologyInternal medicineArtificial intelligenceBiochemistryCAR-T cell therapy researchViral Infectious Diseases and Gene Expression in InsectsAdvancements in Semiconductor Devices and Circuit Design