Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism
Yin Hu, Yan Zhang, Chu-Yu Ni, Chun‐Yuan Chen, Shan‐Shan Rao, Hao Yin, Jie Huang, Yi‐Juan Tan, Zhen‐Xing Wang, Jia Cao, Zhengzhao Liu, Pingli Xie, Ben Wu, Juan Luo, Hui Xie
Abstract
Our results suggest that hucMSC-EVs serve as a critical regulator of bone metabolism by transferring CLEC11A and may represent a potential agent for prevention and treatment of osteoporosis.
Topics & Concepts
Mesenchymal stem cellStromal cellUmbilical cordExtracellularCell biologyExtracellular vesiclesMicrovesiclesChemistryBone remodelingBone cellBone marrowMetabolismCancer researchPathologyPharmacologyMedicineBiologyImmunologyBiochemistryEndocrinologymicroRNAGeneExtracellular vesicles in diseaseMicroRNA in disease regulationCircular RNAs in diseases