Formate and CO<sub>2</sub> Enable Reductive Carboxylation of Imines: Synthesis of Unnatural α-Amino Acids
Pei Xu, Wenwen Liu, Tian-Zi Hao, Yiqin Liu, Hui-Xian Jiang, Jing Xu, Jin-You Li, Long Yin, Songlei Zhu, Xu Zhu
Abstract
Herein, a photocatalytic umpolung strategy for reductive carboxylation of imines for the synthesis of α-amino acids was disclosed. Carbon dioxide radical anion (CO 2 •– ) generated from formate is the key single electron reductant in the reactions. An unprecedentedly broad substrate scope of imines with excellent reaction yields was obtained with carbon dioxide (CO 2 ) and formate salt as carbon sources.
Topics & Concepts
ChemistryCarboxylationFormateCombinatorial chemistryReductive eliminationAmino acidOrganic chemistryCatalysisBiochemistryCarbon dioxide utilization in catalysisAsymmetric Hydrogenation and CatalysisCO2 Reduction Techniques and Catalysts