Antibody–bottlebrush prodrug conjugates for targeted cancer therapy
Bin Liu, Hung V.‐T. Nguyen, Yivan Jiang, Aiden Wang, Valerie Lensch, Zehao Sun, Zane Boyer, Philip A Raftopoulos, Yutong Dai, Piper L MacNicol, Yuyan Wang, Nidhi Jyotsana, Wencong Wang, Sachin Bhagchandani, Sanjana Hemdev, Peyton Shieh, Samantha L. Kristufek, Magalie Boucher, Michael Downes, Ronald M. Evans, David W. C. MacMillan, Jeremiah A. Johnson
Topics & Concepts
ProdrugConjugateMonoclonal antibodyChemistryDrugCombinatorial chemistryConjugated systemCancer therapyPolyethylene glycolTargeted therapyCancer researchCancer cellTargeted drug deliveryAntibody-drug conjugateCancer immunotherapyNanotechnologyMUC1InternalizationCytotoxicityAntibodyComputational biologyDrug deliveryPharmacologyFlexibility (engineering)ImmunotherapyCovalent bondCetuximabTumor cellsMonoclonal and Polyclonal Antibodies ResearchClick Chemistry and ApplicationsHER2/EGFR in Cancer Research