Enhanced relaxivity of Gd<sup>III</sup>-complexes with HP-DO3A-like ligands upon the activation of the intramolecular catalysis of the prototropic exchange
Luciano Lattuada, David Horváth, Sonia Colombo Serra, Alberto Fringuello Mingo, Paolo Minazzi, Attila Bényei, Attila Forgács, Franco Fedeli, Eliana Gianolio, Silvio Aime, Giovanni B. Giovenzana, Zsolt Baranyai
Abstract
The simple modification of the hydroxypropyl arm in Gd(HP-DO3A) complex allows to achieve an increased relaxivity by the activation of the intramolecular catalysis of the proton exchange process.
Topics & Concepts
Intramolecular forceCatalysisChemistryProtonInorganic chemistryStereochemistryOrganic chemistryPhysicsQuantum mechanicsLanthanide and Transition Metal ComplexesMagnetism in coordination complexesRadioactive element chemistry and processing