Ticagrelor vs Prasugrel in Patients With Diabetes and Multivessel Coronary Artery Disease
S Bangalore, Santosh Kumar Sinha, Rakendra Singh, Ashok Kumar Parida, Rohit Mody, Rajpal Abhaichand, Darshan Banker, Aziz Khan, Arun Kalyansundaram, Nagaraja Moorthy, Kunal Mahajan, B. Mohan, Bhaveesh Meel, Rajpal Singh, Sanjay Porwal, Ajit Bhagwat, Charantharayail Gopalan Bahuleyan, Deepak Davidson, Sudheer Koganti, Sunil Kumar Garsa, Kerkar Pg, Gopala Krishna Koduru, Madhu Sreedharan, Prashant Jagtap, G. Manohar, Santosh Kumar, Priyadarshini Arambam, Nagma Khan, Varsha Koul, Krishnankutty Sudhir, U Kaul, TUXEDO-2 India Investigators, Rajesh Sharma, Sharad Chandra, Neil Bordoloi, Dilip Kumar, Sarat P. Chandra, Sengottuvelu Gunasekaran, Rajneesh Kapoor, Rituparno Baruah, Raja Ram Mantri, Ravikant Patil, Yashpaul Sharma, Deepesh Kumar Agrawal, Polavarapu Veera Raghava Sharma, Rajeev Garg, Praveen Chandra, Prakash Ajmera, Jaspal Arneja, Subhash Chandra, Nityanand Tripathi, Aditya Batra, Dhiman Kahali, Shuvanan Ray, Jay M. Shah, Vishal Anand Poptani, Jaskaran Singh Dugal, Anil Potdar, Pravin Kumar Goel, Rishi Sethi, Praveen SV, Arijit Ghosh, Keshava Ramaiah, Rony Mathew, John F. John, Nirav Bhalani, Rajesh Badani, Balbir Singh, C Raghu, Ramesh Natarajan, Narsimha Pai, Dheeraj Gandotra, Sai Sudhakar, Prashant Panda, Sanjay Tyagi, Rakesh Yadav, Johann Christopher, Santosh Kumar, Yumnam Diana Devi, Siddhi Maheswari, Dushyant Sharma, Anjali Bhatt, Tamanpreet Kaur
Abstract
Importance: The optimal dual antiplatelet therapy after percutaneous coronary intervention (PCI) in patients with diabetes is not clearly defined. Although both ticagrelor and prasugrel are potent inhibitors of P2Y purinergic receptor 12 (P2Y12), evidence directly comparing their efficacy and safety in this high-risk group remains limited. Objective: To compare the clinical outcomes of ticagrelor vs prasugrel, each in combination with aspirin, in patients with diabetes and multivessel coronary artery disease who underwent percutaneous coronary intervention. Design, Setting, and Participants: The Ultrathin Strut vs Xience in a Diabetic Population With Multivessel Disease 2-India Study (TUXEDO-2) is an investigator-initiated, prospective, open-label, multicenter, 2 × 2 factorial design, 1:1 randomized clinical trial. Participants with diabetes and multivessel disease undergoing percutaneous coronary intervention were enrolled at 66 clinical sites from February 2020 to August 2024. Interventions: Patients undergoing percutaneous coronary intervention were randomized to receive either ticagrelor or prasugrel, each in combination with low-dose aspirin. Main Outcomes and Measures: The primary outcome was a composite of death, nonfatal myocardial infarction, stroke, or major bleeding as defined by the Bleeding Academic Research Consortium at 1 year. The trial was designed to test the noninferiority of ticagrelor compared with prasugrel with a noninferiority margin of 5%. Results: Among the 1800 participants randomized, mean (SD) age was 60 (10) years with 1296 (72.0%) male participants, 436 (24.2%) receiving insulin therapy, and 1530 (85.0%) with triple-vessel disease. At 1 year, the primary end point occurred in 129 participants (16.6%) taking ticagrelor and 107 participants (14.2%) taking prasugrel (P = .12). The risk difference of 2.33 percentage points (95% CI, -2.07 to 6.74 percentage points) failed to meet the prespecified threshold for noninferiority (P = .84). There was numerically higher (but not statistically significant) composite of death, myocardial infarction, stroke (10.43% vs 8.63%; P = .30), and major bleeding (8.41% vs 7.14%; P = .19) with ticagrelor when compared with prasugrel. Conclusions and Relevance: In patients with diabetes and multivessel disease undergoing PCI, ticagrelor was not noninferior to prasugrel for the reduction of primary outcome at 1 year of follow-up. Trial Registration: CTRI/2019/11/022088.