Protocol of the Healthy Brain Study: An accessible resource for understanding the human brain and how it dynamically and individually operates in its bio-social context
Esther Aarts, Agnes Akkerman, Mareike Altgassen, Ronald Bartels, Debby G. J. Beckers, Kirsten E. Bevelander, Erik Bijleveld, Esmeralda Blaney Davidson, Annemarie Boleij, Janita Bralten, Toon Cillessen, Jurgen A.H.R. Claassen, Roshan Cools, Ineke Cornelissen, Martin Dresler, Thijs M.H. Eijsvogels, Myrthe Faber, Guillén Fernández, Bernd Figner, Matthias Fritsche, Sascha Füllbrunn, Surya Gayet, Marleen M. H. J. van Gelder, Marcel van Gerven, Sabine A. E. Geurts, Corina U. Greven, Martine Groefsema, Koen V. Haak, Peter Hagoort, Yvonne Hartman, Béatrice van der Heijden, Erno J. Hermans, Vivian Heuvelmans, Florian Hintz, Janet den Hollander, Anneloes M. Hulsman, Sebastián Idesis, Martin Jaeger, Esther Janse, Joost Janzing, Roy P. C. Kessels, Johan C. Karremans, Willemien de Kleijn, Marieke Klein, Floris Klumpers, Nils Kohn, Hubert Korzilius, Bas Krahmer, Floris P. de Lange, Judith van Leeuwen, Huaiyu Liu, Maartje Luijten, Peggy Manders, Katerina Manevska, José P. Marques, Jon Matthews, James M. McQueen, Pieter Medendorp, René J. F. Melis, Antje S. Meyer, Joukje M. Oosterman, Lucy Overbeek, Marius V. Peelen, J. Popma, Geert Postma, Karin Roelofs, Yvonne Van Rossenberg, Gabi Schaap, Paul T.J. Scheepers, Luc P. J. Selen, Marianne Starren, Dorine W. Swinkels, Indira Tendolkar, Dick H. J. Thijssen, Hans Timmerman, Rayyan Tutunji, Anil M. Tuladhar, Harm Veling, Maaike Verhagen, Jasper Verkroost, Jacqueline M. Vink, Vivian Vriezekolk, Janna N. Vrijsen, Jana Vyrastekova, Selina van der Wal, Roel Willems, Arthur Willemsen
Abstract
The endeavor to understand the human brain has seen more progress in the last few decades than in the previous two millennia. Still, our understanding of how the human brain relates to behavior in the real world and how this link is modulated by biological, social, and environmental factors is limited. To address this, we designed the Healthy Brain Study (HBS), an interdisciplinary, longitudinal, cohort study based on multidimensional, dynamic assessments in both the laboratory and the real world. Here, we describe the rationale and design of the currently ongoing HBS. The HBS is examining a population-based sample of 1,000 healthy participants (age 30-39) who are thoroughly studied across an entire year. Data are collected through cognitive, affective, behavioral, and physiological testing, neuroimaging, bio-sampling, questionnaires, ecological momentary assessment, and real-world assessments using wearable devices. These data will become an accessible resource for the scientific community enabling the next step in understanding the human brain and how it dynamically and individually operates in its bio-social context. An access procedure to the collected data and bio-samples is in place and published on https://www.healthybrainstudy.nl/en/data-and-methods/access. Trail registration: https://www.trialregister.nl/trial/7955.