B Cell Receptor-Responsive miR-141 Enhances Epstein-Barr Virus Lytic Cycle via FOXO3 Inhibition
Yan Chen, Devin N. Fachko, Nikita S. Ivanov, Rebecca L. Skalsky
Abstract
EBV is a human pathogen associated with several malignancies. A key aspect of lifelong virus persistence is the ability to switch between latent and lytic replication modes. The mechanisms governing latency, reactivation, and progression of the lytic cycle are only partly understood. This study reveals that specific miRNAs can act to support the EBV lytic phase following BCR-mediated reactivation triggers. Furthermore, this study identifies a role for FOXO3, commonly suppressed by both host and viral miRNAs, in modulating progression of the EBV lytic cycle.
Topics & Concepts
Lytic cycleBiologymicroRNAEpstein–Barr virusVirusCell cycleCell biologyVirologyGeneGeneticsViral-associated cancers and disordersCancer-related molecular mechanisms researchCircular RNAs in diseases