Cascade Transformations of [1,2,3]Triazolo[1,5-a]pyridines as Convenient Precursors of Diazo Compounds and Metal Carbenes
Yury N. Kotovshchikov, Vladislav A. Voloshkin, Gennadij V. Latyshev, N. V. Lukashev, I. P. Beletskaya
Abstract
The review is devoted to the use of [1,2,3]triazolo[1,5-a]pyridines as precursors of tautomeric 2-(diazomethyl)pyridines. This methodology represents a convenient tool for the synthesis of various types of nitrogen-containing heterocycles. Both noncatalytic transformations and cascade reactions involving metal carbenes, which have been intensively studied in recent years, are considered. Major approaches to the preparation of [1,2,3]triazolo[1,5-a]pyridines are also summarized in the review.
Topics & Concepts
ChemistryDiazoTautomerCascadeCombinatorial chemistryMetalOrganic chemistryComputational chemistryChromatographyCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsSynthesis and Reactivity of Heterocycles