Apelin regulates skeletal muscle adaptation to exercise in a high-intensity interval training model
Teemu Kilpiö, Sini Skarp, Ábel Perjés, Julia Swan, Leena Kaikkonen, Samu Saarimäki, István Szokodi, Josef Penninger, Zoltán Szabó, Johanna Magga, Risto Kerkelä
Abstract
Apelin levels decline with age. This study demonstrates that in trained mice, apelin deficiency results in a switch from fast type II myofibers to slow oxidative type I myofibers. This is associated with a concomitant change in gene expression profile toward fatty acid utilization, indicating an aged-muscle phenotype in exercised apelin-deficient mice. These data are of importance in the design of exercise programs for aging individuals and could offer therapeutic target to maintain muscle mass.
Topics & Concepts
ApelinSkeletal muscleInternal medicineEndocrinologyMyogenesisMyocyteMuscle hypertrophyDownregulation and upregulationMyosinChemistryBiologyCell biologyMedicineBiochemistryReceptorGeneApelin-related biomedical researchParaoxonase enzyme and polymorphismsCardiovascular, Neuropeptides, and Oxidative Stress Research