Synthesis of Hydrobenzoimidazoles from <i>para</i>‐Quinamines and 1,3,5‐Triazinanes via a Formal [3+2] Annulation Reaction
Xin‐Ping Zhang, Bin Cheng, Hui Li, Yixuan He, Wei Xu, Xiaoguang Duan, Haiyan Sun, Taimin Wang, Hongbin Zhai
Abstract
Abstract The synthesis of hydrobenzoimidazoles from para ‐quinamines and 1,3,5‐triazinanes was achieved via a formal [3+2] annulation reaction in the presence of In(OTf) 3 as the catalyst. Further studies demonstrated that the synthesis of hydrobenzooxazoles could also be accomplished via the same strategy from para ‐quinols and 1,3,5‐triazinanes. magnified image
Topics & Concepts
AnnulationChemistryFormal synthesisCatalysisCombinatorial chemistryStereochemistryOrganic chemistrySynthesis and Biological EvaluationCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions