Multimodal deep learning improves recurrence risk prediction in pediatric low-grade gliomas
Maryamalsadat Mahootiha, Divyanshu Tak, Zezhong Ye, Anna Zapaishchykova, Jirapat Likitlersuang, Juan Carlos Pardo, Aidan Boyd, Sridhar Vajapeyam, Rishi Chopra, Sanjay P. Prabhu, Kevin X. Liu, Hesham Elhalawani, Ali Nabavizadeh, Ariana Familiar, Sabine Mueller, Hugo J.W.L. Aerts, Pratiti Bandopadhayay, Keith L. Ligon, Daphne A. Haas‐Kogan, Tina Young Poussaint, Hemin Ali Qadir, Ilangko Balasingham, Benjamin H. Kann
Abstract
BACKGROUND: Postoperative recurrence risk for pediatric low-grade gliomas (pLGGs) is challenging to predict by conventional clinical, radiographic, and genomic factors. We investigated if deep learning (DL) of magnetic resonance imaging (MRI) tumor features could improve postoperative pLGG risk stratification. METHODS: We used a pretrained DL tool designed for pLGG segmentation to extract pLGG imaging features from preoperative T2-weighted MRI from patients who underwent surgery (DL-MRI features). Patients were pooled from 2 institutions: Dana Farber/Boston Children's Hospital (DF/BCH) and the Children's Brain Tumor Network (CBTN). We trained 3 DL logistic hazard models to predict postoperative event-free survival (EFS) probabilities with (1) clinical features, (2) DL-MRI features, and (3) multimodal (clinical and DL-MRI features). We evaluated the models with a time-dependent Concordance Index (Ctd) and risk group stratification with Kaplan-Meier plots and log-rank tests. We developed an automated pipeline integrating pLGG segmentation and EFS prediction with the best model. RESULTS: Of the 396 patients analyzed (median follow-up: 85 months, range: 1.5-329 months), 214 (54%) underwent gross total resection and 110 (28%) recurred. The multimodal model improved EFS prediction compared to the DL-MRI and clinical models (Ctd: 0.85 (95% CI: 0.81-0.93), 0.79 (95% CI: 0.70-0.88), and 0.72 (95% CI: 0.57-0.77), respectively). The multimodal model improved risk-group stratification (3-year EFS for predicted high-risk: 31% versus low-risk: 92%, P < .0001). CONCLUSIONS: DL extracts imaging features that can inform postoperative recurrence prediction for pLGG. Multimodal DL improves postoperative risk stratification for pLGG and may guide postoperative decision-making. Larger, multicenter training data may be needed to improve model generalizability.