Novel piperazine–chalcone hybrids and related pyrazoline analogues targeting VEGFR-2 kinase; design, synthesis, molecular docking studies, and anticancer evaluation
Marwa F. Ahmed, Eman Y. Santali, Radwan El‐Haggar
Abstract
as a reference ligand.
Topics & Concepts
ChalconePyrazolineDocking (animal)ChemistryApoptosisAnnexinCell cycle checkpointCell cyclePiperazineProtein Data Bank (RCSB PDB)SorafenibCell cultureBiochemistryPharmacologyStereochemistryCancer researchBiologyMedicineOrganic chemistryNursingGeneticsHepatocellular carcinomaSynthesis and biological activityAngiogenesis and VEGF in CancerBioactive Compounds and Antitumor Agents