Nickel-catalyzed cross-electrophile coupling of aryl thiols with aryl bromides <i>via</i> C–S bond activation
Hao Xu, Cai-Yu He, Bo‐Jie Huo, Jia-Wen Jing, Chengping Miao, Weidong Rao, Xue‐Qiang Chu, Xiaocong Zhou, Zhi‐Liang Shen
Abstract
We report a cross-electrophile coupling of aryl thiols with aryl bromides via C–S bond activation instead of S–H bond cleavage. The reaction proceeded effectively in the presence of a nickel catalyst, magnesium, and lithium chloride to afford various biaryls in moderate to good yields.
Topics & Concepts
ChemistryArylElectrophileCatalysisNickelMedicinal chemistryMagnesiumBond cleavageChlorideCleavage (geology)Coupling reactionOrganic chemistryAlkylFracture (geology)Geotechnical engineeringEngineeringSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsCatalytic C–H Functionalization Methods