A modest change in housing temperature alters whole body energy expenditure and adipocyte thermogenic capacity in mice
D Sadler, Lillie Treas, James D. Sikes, Craig Porter
Abstract
Housing mice at 30°C reduced the basal and total energy expenditure compared with 24°C, which was accompanied by a reduction in brown adipose tissue UCP1 content. Proteomic profiling demonstrated the brown adipose tissue and white adipose tissue proteomes were largely influenced by housing temperature and sex, respectively. Therefore, 30°C housing revealed sexual dimorphism in the white adipose tissue proteome that was largely absent in animals housed at 24°C.
Topics & Concepts
ThermogenesisBrown adipose tissueThermogeninAdipose tissueInternal medicineWhite adipose tissueEndocrinologyEnergy expenditureChemistryBiologyAdipocyteMedicineAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesExercise and Physiological Responses