TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions
Jimmy J. Weterings, Cristianne J.F. Rijcken, Harald Veldhuis, Tommi Meulemans, Darya Hadavi, Matt Timmers, Maarten Honing, Hans Ippel, Rob M. J. Liskamp
Abstract
) as a superior click reagent. This reagent combines a great reactivity, with small size and low hydrophobicity and compares outstandingly with existing click reagents. TMTHSI can be conveniently functionalized with a variety of linkers allowing attachment of a diversity of small molecules and (peptide, nucleic acid) biologics.
Topics & Concepts
AlkyneCycloadditionAzideReagentChemistryRing (chemistry)Strain (injury)Combinatorial chemistryCatalysisOrganic chemistryBiologyAnatomyClick Chemistry and ApplicationsAdvanced Biosensing Techniques and ApplicationsMolecular Junctions and Nanostructures