Seventh BHD international symposium: recent scientific and clinical advancement

Abstract

// Mark R. Woodford 1 , 2 , 3 , Avgi Andreou 4 , Masaya Baba 5 , Irma van de Beek 6 , Chiara Di Malta 7 , 8 , Iris Glykofridis 9 , Hannah Grimes 10 , Elizabeth P. Henske 11 , Othon Iliopoulos 12 , 13 , Masatoshi Kurihara 14 , Romain Lazor 15 , W. Marston Linehan 16 , Kenki Matsumoto 17 , Stefan J. Marciniak 10 , Yukiko Namba 18 , Arnim Pause 19 , Neil Rajan 20 , Anindita Ray 21 , Laura S. Schmidt 22 , Wei Shi 23 , Ortrud K. Steinlein 24 , Julia Thierauf 25 , 26 , Roberto Zoncu 27 , Anna Webb 28 and Mehdi Mollapour 1 , 2 , 3 1 Department of Urology, SUNY Upstate Medical University, Syracuse, NY, USA 2 Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA 3 Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY, USA 4 Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK 5 International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan 6 Department of Human Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands 7 Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy 8 Medical Genetics Unit, Department of Medical and Translational Science, Federico II University, Naples, Italy 9 Amsterdam UMC, Location VUmc, Human Genetics Department, Cancer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands 10 Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK 11 Center for LAM Research and Clinical Care, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA 12 Center for Cancer Research, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA 13 Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA 14 Pneumothorax Research Center and Division of Thoracic Surgery, Nissan Tamagawa Hospital, Setagayaku, Tokyo, Japan 15 Respiratory Medicine Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland 16 Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA 17 Department of Respiratory Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK 18 Division of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan 19 Department of Biochemistry, Goodman Cancer Research Institute, McGill University, Montréal, Canada 20 Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK 21 Indian Statistical Institute, Kolkata, WB, India 22 Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA 23 The Saban Research Institute, Children's Hospital Los Angeles, The Keck School of Medicine, University of Southern California, Los Angeles, CA, USA 24 Institute of Human Genetics, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, Germany 25 Department of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA 26 Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital and Research Group Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center (DKFZ), Heidelberg, Germany 27 Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, USA 28 The BHD Foundation, The Myrovlytis Trust, London, UK Correspondence to: Mehdi Mollapour, email: [email protected] Keywords: Birt-Hogg-Dubé syndrome; folliculin; FLCN; tuberous sclerosis complex; LDHA Received: December 23, 2021     Accepted: December 25, 2021     Published: January 20, 2022 Copyright: © 2022 Woodford et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT The 7th Birt-Hogg-Dubé (BHD) International Symposium convened virtually in October 2021. The meeting attracted more than 200 participants internationally and highlighted recent findings in a variety of areas, including genetic insight and molecular understanding of BHD syndrome, structure and function of the tumor suppressor Folliculin (FLCN), therapeutic and clinical advances as well as patients’ experiences living with this malady.

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