Novel pyrazine based anti-tubercular agents: Design, synthesis, biological evaluation and in silico studies
Nayera W. Hassan, Manal N. Saudi, Yasser S. Abdel‐Ghany, Azza Ismail, Perihan A. Elzahhar, Dharmarajan Sriram, Rasha A. Nassra, Marwa M. Abdel‐Aziz, Soad A. El-Hawash
Topics & Concepts
PharmacophoreIn silicoChemistryMycobacterium tuberculosisDocking (animal)In vitroActive sitePyrazineCombinatorial chemistryPyrazinamideStereochemistryBiochemistryComputational biologyEnzymeAntimycobacterialRifampicinTuberculosisAntibioticsGeneBiologyPathologyNursingMedicineTuberculosis Research and EpidemiologyComputational Drug Discovery MethodsCancer therapeutics and mechanisms